A recent study suggests that individuals who stop using new slimming jabs like semaglutide or tirzepatide may regain shed pounds far faster than those who halt conventional lifestyle plans.
Findings released in a leading medical journal points out that while obese people frequently drop about a fifth of their body weight while on the medication, the mass comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals using these treatments should be cognizant of the risk of quick rebound weight gain when the treatment concludes," stated expert Dr. Susan Jebb.
That rate of regain means a return to original weight within about 18 months.
Comparing Treatments
The analysis, which reviewed 37 of studies involving over 9,000 of patients, compared the outcomes of the injectable medications with older methods.
The team emphasize that people who shed pounds through dieting usually see a slower weight regain—around 0.1 kg a month—after stopping.
The Reason for the Quick Regain
Nutrition scientists suggest the mode of action of the injections accounts for the amplified weight return.
The injections copy a body's own chemical called GLP-1, which helps regulate feelings of fullness.
"Long-term administration of GLP-1 concentrations several times higher than normal may cause the body to produce less of its own natural hormone, and could reduce responsiveness to its effects," explained Dr. Adam Collins, a nutrition researcher.
"Stopping of this GLP-1 'fix' means hunger is no longer kept in check, making excessive eating far more likely."
A Chronic Condition?
The NHS suggest the injections for individuals with obesity-related health risks, accompanied by recommended lifestyle changes.
Many experts contend that, due to the likelihood of weight regain, the treatment might need to be ongoing.
This view is echoed by pharmaceutical companies, who note that the results "highlight the chronic character of obesity," akin to managing diseases like diabetes.
User Testimonies
Individuals who have stopped the medication explain a intense resurgence of cravings.
"It felt as if a switch that goes on and you become extremely hungry," said one woman.
This challenge is exacerbated if individuals have not developed sustainable dietary or behavioural modifications during therapy.
Widespread Adoption
Figures show that millions of people in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Use is greater among females compared to men.
- The middle-aged age group shows the highest usage rates.
- A large proportion access the drugs through private healthcare rather than the NHS.
Ultimately, experts stress that while these medications are effective agents for weight loss, they are not a permanent cure and lasting health benefits relies on integrated lifestyle changes.
